Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977401 | 0.89 | KMT2A (0.48) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2977008 | 0.89 | NPC1 (0.47) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2968665 | 0.85 | NPC1 (0.44) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2976173 | 0.83 | USP30 (0.42) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2961761 | 0.81 | NPC1 (0.52) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2977071 | 0.81 | ALDH1A1 (0.53) | RAB9AKMT2ACFTRPTAFRHPGD | |
| SCHEMBL2972524 | 0.81 | NPC1 (0.51) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2979187 | 0.79 | KMT2A (0.51) | NPC1RAB9ACDK4CCND1KMT2A | |
| SCHEMBL2977501 | 0.79 | NPC1 (0.49) | NPC1RAB9AKMT2ACFTRPTAFR | |
| SCHEMBL2967147 | 0.79 | KMT2A (0.57) | NPC1RAB9AKMT2ACFTRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |