Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 17/20 | 0.55 |
| ▸ | AURKC | Q9UQB9 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220965 | 0.89 | AURKA (0.56) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13220978 | 0.86 | AURKA (0.42) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13324827 | 0.84 | AURKB (0.61) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13220964 | 0.84 | AURKB (0.57) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL3044546 | 0.83 | AURKB (0.60) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13220986 | 0.83 | AURKB (0.60) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13221253 | 0.80 | AURKB (0.54) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13220956 | 0.80 | AURKB (0.57) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13220989 | 0.79 | AURKB (0.58) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL13221252 | 0.78 | AURKB (0.51) | AURKAAURKBAURKCSRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288536-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-8288536-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20100216765-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
| US-20100216765-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216765-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K1 | AURKA 161/4885AURKB 122/4885AURKC 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.