Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 17/20 | 0.61 |
| ▸ | AURKA | O14965 | 16/20 | 0.61 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324824 | 0.89 | AURKA (0.59) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL13220962 | 0.84 | AURKA (0.55) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL13324826 | 0.81 | AURKB (0.63) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL13220981 | 0.78 | AURKB (0.61) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL5070928 | 0.74 | AURKB (0.64) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL13220965 | 0.74 | AURKA (0.56) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL13220978 | 0.74 | AURKA (0.42) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL12430843 | 0.73 | AURKB (1.00) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL12430846 | 0.72 | AURKB (0.76) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL5069306 | 0.72 | AURKB (0.63) | AURKBAURKAAURKCSRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |