Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203552 | 0.92 | HDAC6 (0.54) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203549 | 0.90 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203544 | 0.89 | HDAC6 (0.52) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL2964659 | 0.88 | HDAC6 (0.60) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203545 | 0.85 | KDM4E (0.59) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203541 | 0.85 | HDAC6 (0.56) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203490 | 0.84 | HDAC6 (0.55) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13220946 | 0.83 | BRD4 (0.58) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13221021 | 0.81 | HDAC6 (0.52) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203499 | 0.76 | NPC1 (0.68) | MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |