Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | APLNR | P35414 | 7/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203541 | 0.90 | HDAC6 (0.56) | KDM4EMAPTHTTHDAC6HDAC3 | |
| SCHEMBL13221011 | 0.85 | HDAC6 (0.56) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL2964659 | 0.84 | HDAC6 (0.60) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL13203552 | 0.84 | HDAC6 (0.54) | KDM4EMAPTHDAC6HDAC3HDAC1 | |
| SCHEMBL13203549 | 0.82 | HDAC6 (0.53) | KDM4EMAPTHDAC6HDAC3HDAC1 | |
| SCHEMBL13203544 | 0.81 | HDAC6 (0.52) | MAPTHDAC6HDAC3HDAC1HDAC8 | |
| SCHEMBL13220946 | 0.80 | BRD4 (0.58) | KDM4EHTTHDAC6HDAC3HDAC1 | |
| SCHEMBL13221099 | 0.78 | KDM4E (0.41) | KDM4EMAPTHTTAPLNRLMNA | |
| SCHEMBL13221021 | 0.78 | HDAC6 (0.52) | KDM4EMAPTHDAC6HDAC3HDAC1 | |
| SCHEMBL13203579 | 0.74 | HDAC6 (0.55) | KDM4EHDAC6HDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |