Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13245241 | 0.87 | MAPK1 (0.49) | MAPK1MEN1KMT2AKDM4EGAA | |
| SCHEMBL25493018 | 0.81 | MEN1 (0.48) | MAPK1MEN1KMT2AKDM4EGAA | |
| SCHEMBL17159811 | 0.76 | EGLN3 (0.56) | MAPK1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13222788 | 0.74 | MEN1 (0.47) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL13222798 | 0.74 | KCNA3 (0.36) | KDM4EALDH1A1TSHRLMNANPC1 | |
| SCHEMBL29518112 | 0.74 | EGLN3 (0.54) | MAPK1MEN1KMT2AKDM4EGAA | |
| SCHEMBL2535061 | 0.74 | EGLN3 (0.54) | MAPK1MEN1KMT2AKDM4EGAA | |
| SCHEMBL738419 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL19018153 | 0.74 | MEN1 (0.39) | MAPK1MEN1KMT2AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL2530861 | 0.72 | EGLN3 (0.52) | MAPK1MEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481483-B2 | Cyclosporin analogues | ENANTA PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481483-B2 | Cyclosporin analogues | ENANTA PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20100209390-A1 | CYCLOSPORIN ANALOGUES | ENANTA PHARMACEUTICALS, INC. | 2010-08-19 | — | — | US | disclosed |
| US-20100209390-A1 | CYCLOSPORIN ANALOGUES | ENANTA PHARMACEUTICALS, INC. | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100209390-A1 | CYCLOSPORIN ANALOGUES | HAVCR2, CHP1, ICOS | MAPK1 1983/4885MEN1 2859/4885KMT2A 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.