Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350065 | 0.90 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10194631 | 0.86 | HDAC6 (0.57) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10144870 | 0.79 | DRD4 (0.60) | KMT2AMAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL10194565 | 0.79 | SFRP1 (0.60) | TPSAB1SFRP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1662900 | 0.78 | HDAC1 (0.71) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10194628 | 0.77 | MCHR1 (0.51) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10194626 | 0.75 | HDAC8 (0.50) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10194627 | 0.75 | HDAC8 (0.59) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1618414 | 0.75 | HDAC6 (0.66) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10194451 | 0.75 | HDAC6 (0.72) | HDAC6HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767679-B2 | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-03 | — | — | US | disclosed |
| US-7767679-B2 | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-03 | — | — | US | disclosed |