SFRP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4615591	1.00	20/20
SCHEMBL4615862	1.00	20/20
SCHEMBL4616029	1.00	20/20
SCHEMBL4616153	1.00	20/20
SCHEMBL4616175	1.00	20/20
SCHEMBL4616331	1.00	20/20
SCHEMBL4616332	1.00	20/20
SCHEMBL4616650	1.00	20/20
SCHEMBL4616690	1.00	20/20
SCHEMBL4616176	0.93	20/20
SCHEMBL4616668	0.90	20/20
SCHEMBL4615956	0.89	20/20
SCHEMBL4615676	0.87	20/20
SCHEMBL4616363	0.87	20/20
SCHEMBL4616032	0.85	20/20
SCHEMBL4616144	0.85	20/20
SCHEMBL4615733	0.84	20/20
SCHEMBL4616139	0.83	20/20
SCHEMBL4616018	0.81	20/20
SCHEMBL4616473	0.81	20/20

Clinical trials — most relevant to SFRP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Foxy-5 as Neo-Adjuvant Therapy in Subjects With Wnt-5a Low Colon Cancer	PHASE2	UNKNOWN
Mesalazine Effects in Sporadic Colorectal Adenoma Patients	PHASE2	COMPLETED
Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer	PHASE2	WITHDRAWN
CAR-T Cell Therapy Targeting GPC3 in Patients with Advanced GPC3-Positive Hepatocellular Carcinoma	PHASE1/PHASE2	NOT_YET_RECRUITING
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel	PHASE2	NOT_YET_RECRUITING
Phase I Study to Evaluate Safety, Tolerability, Anti-Tumour Activity and PK Profiles of Foxy-5 in Metastatic Breast, Colon or Prostate Cancer	PHASE1	COMPLETED
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer Prevention	PHASE1	WITHDRAWN
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma	nan	ACTIVE_NOT_RECRUITING
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling	nan	COMPLETED
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment	nan	COMPLETED
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients	nan	UNKNOWN
Intestinal Stem Cells Characterization	nan	COMPLETED
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors	nan	NO_LONGER_AVAILABLE
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis	nan	RECRUITING
Exploratory Study of Rectal Mucus for Diagnosing Disease	nan	COMPLETED
Cycling Duration and Bone Markers in in Active Young Adults	nan	WITHDRAWN
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Role of CTHRC1 in Diagnosis of Rheumatoid Arthritis	nan	UNKNOWN
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Identification of Biomarkers for Early Detection of Pancreatic Cancer	nan	COMPLETED
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
H19 in Acute Lymphoblastic Leukemia.	nan	UNKNOWN
Prospective Breast Cancer Biobanking	nan	ENROLLING_BY_INVITATION
Genetic Analysis of Childhood Obesity	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SFRP1 binder may also engage these)

Protein	Name	Similarity
Q8C4U3	—	1.000	Q8C4U3 →
O19116	—	1.000	O19116 →
Q9DEQ4	—	0.988	Q9DEQ4 →
Q92765	—	0.987	Q92765 →
Q5RF67	—	0.986	Q5RF67 →
Q95117	—	0.984	Q95117 →
P97401	—	0.982	P97401 →
Q9IA95	—	0.979	Q9IA95 →
Q863H1	—	0.968	Q863H1 →
P97299	—	0.966	P97299 →
Q96HF1	—	0.959	Q96HF1 →
Q9R1E9	—	0.950	Q9R1E9 →
O18739	—	0.950	O18739 →
A0A1D5PUP4	—	0.950	A0A1D5PUP4 →
P29268	—	0.950	P29268 →
P29279	—	0.949	P29279 →
O95980	—	0.947	O95980 →
O19113	—	0.947	O19113 →
Q5U4X8	—	0.947	Q5U4X8 →
P52799	—	0.947	P52799 →
Q02353	—	0.946	Q02353 →
Q8TDF5	—	0.946	Q8TDF5 →
Q91987	—	0.944	Q91987 →
P27090	—	0.944	P27090 →
Q3UHN9	—	0.944	Q3UHN9 →
Q9P0K1	—	0.944	Q9P0K1 →
P61811	—	0.944	P61811 →
O73612	—	0.944	O73612 →
P52800	—	0.943	P52800 →
Q99J86	—	0.943	Q99J86 →