Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13226504 | 0.91 | CCR2 (0.52) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13226503 | 0.88 | CCR2 (0.49) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13226507 | 0.88 | CCR2 (0.49) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13226328 | 0.81 | CCR2 (0.64) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13226329 | 0.81 | CCR2 (0.61) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13254223 | 0.81 | CCR2 (0.61) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13226490 | 0.80 | CCR2 (0.60) | CCR2CCR1TMEM97SIGMAR1KCNH2 | |
| SCHEMBL13759418 | 0.79 | CCR2 (0.48) | CCR2CCR1TMEM97SIGMAR1 | |
| SCHEMBL14599243 | 0.79 | CCR2 (0.47) | CCR2 | |
| SCHEMBL14599233 | 0.79 | CCR2 (0.52) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786305-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7230008-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK & CO, INC. (US) | 2007-06-12 | — | — | US | disclosed |