Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125579 | 0.83 | HDAC3 (0.62) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL11988227 | 0.83 | SMN1; SMN2 (0.64) | RAB9ASMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL7783678 | 0.82 | HDAC1 (0.66) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5536448 | 0.81 | MAPK1 (0.69) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL29721986 | 0.81 | MAPK1 (0.69) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL13233264 | 0.80 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL3223491 | 0.79 | KDM1A (0.60) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL13263765 | 0.78 | CETP (0.67) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL13416408 | 0.78 | KDM1A (0.68) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL9157833 | 0.77 | MAPT (0.60) | RAB9ASMN1; SMN2ALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750151-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| US-20080280899-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280899-A1 | Inhibitors of Akt Activity | AKT1, AKT2, AKT3 | RAB9A 3792/4885SMN1; SMN2 4027/4885NPC1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.