Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234364 | 0.94 | RAF1 (0.62) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234576 | 0.88 | RAB9A (0.72) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL668246 | 0.87 | RAF1 (0.71) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18781528 | 0.85 | RAF1 (0.60) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234371 | 0.85 | RAF1 (0.86) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234374 | 0.85 | RAF1 (0.62) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234376 | 0.84 | RAF1 (0.70) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13264509 | 0.83 | RAF1 (0.60) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234659 | 0.83 | RAF1 (0.71) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234363 | 0.82 | RAF1 (0.67) | RAF1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |