Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 1.00 |
| ▸ | KDR | P35968 | 3/20 | 1.00 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 4/20 | 0.66 |
| ▸ | CSF1R | P07333 | 3/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.66 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946067 | 0.90 | RAF1 (0.82) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL14422914 | 0.90 | RAF1 (0.82) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL939254 | 0.89 | RAF1 (0.80) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL3474850 | 0.87 | RAF1 (0.76) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL20434952 | 0.87 | RAF1 (0.77) | RAF1KDRFLT3CSF1RMAPK3 | |
| SCHEMBL13234879 | 0.87 | RAF1 (0.77) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL15574401 | 0.87 | RAF1 (0.77) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL938059 | 0.86 | RAF1 (0.78) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL668800 | 0.86 | RAF1 (1.00) | RAF1KDRRIPK2MAPK13MAPK14 | |
| SCHEMBL257980 | 0.85 | RAF1 (0.82) | RAF1KDRRIPK2MAPK13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | RAF1 372/4885KDR 1094/4885RIPK2 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.