Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.76 |
| ▸ | KDR | P35968 | 2/20 | 0.76 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475376 | 0.92 | RAF1 (0.64) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL938160 | 0.88 | RAF1 (0.66) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL13234850 | 0.87 | RAF1 (1.00) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL939254 | 0.86 | RAF1 (0.80) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL937729 | 0.85 | RAF1 (0.83) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL14422915 | 0.81 | RAF1 (0.68) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL13946067 | 0.81 | RAF1 (0.82) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL668545 | 0.80 | RAF1 (0.59) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL14422914 | 0.79 | RAF1 (0.82) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL20434952 | 0.78 | RAF1 (0.77) | RAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838541-B2 | Aryl ureas with angiogenesis inhibiting activity | BAYER HEALTHCARE, LLC (US) | 2010-11-23 | — | — | US | claimed |