Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.78 |
| ▸ | RAF1 | P04049 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234417 | 0.89 | MAPK14 (0.83) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234434 | 0.88 | MAPK14 (1.00) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL18232987 | 0.87 | MAPK14 (0.76) | MAPK14RAF1ALDH1A1NTRK1RET | |
| Hydrochloric Acid SCHEMBL1698629 | 0.86 | MAPK14 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234412 | 0.86 | MAPK14 (0.79) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL28417983 | 0.86 | MAPK14 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234440 | 0.85 | MAPK14 (0.73) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234433 | 0.85 | RAF1 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234595 | 0.83 | RAF1 (0.71) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL667912 | 0.82 | RAF1 (0.70) | MAPK14RAF1ALDH1A1NTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | MAPK14 1436/4885RAF1 372/4885ALDH1A1 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.