Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.73 |
| ▸ | RAF1 | P04049 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667588 | 0.85 | RAF1 (0.72) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234417 | 0.85 | MAPK14 (0.83) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13239491 | 0.85 | MAPK14 (0.78) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234434 | 0.84 | MAPK14 (1.00) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL18232987 | 0.84 | MAPK14 (0.76) | MAPK14RAF1ALDH1A1NTRK1RET | |
| Hydrochloric Acid SCHEMBL1698629 | 0.83 | MAPK14 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234412 | 0.83 | MAPK14 (0.79) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL28417983 | 0.83 | MAPK14 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13234433 | 0.82 | RAF1 (0.74) | MAPK14RAF1ALDH1A1NTRK1RET | |
| SCHEMBL13199944 | 0.80 | ALDH1A1 (0.51) | MAPK14RAF1ALDH1A1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |