Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 13/20 | 0.64 |
| ▸ | CCNB2 | O95067 | 12/20 | 0.64 |
| ▸ | CCNB3 | Q8WWL7 | 12/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 9/20 | 0.61 |
| ▸ | CDC7 | O00311 | 3/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | PRKACA | P17612 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239582 | 0.83 | CCNB2 (0.71) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL13239587 | 0.80 | CCNB2 (0.64) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL8939719 | 0.80 | CCNT1 (0.69) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL8939628 | 0.80 | CDK2 (0.69) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL8939641 | 0.79 | ROCK1 (0.65) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL8939623 | 0.78 | CCNB2 (0.61) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL13887929 | 0.78 | ROCK1 (0.70) | CDK2CCNA2CDK5CDK5R1GSK3B | |
| SCHEMBL2544992 | 0.78 | CCNB2 (1.00) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL3773731 | 0.78 | CDK1 (0.79) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL3781298 | 0.78 | CCNB2 (0.79) | CDK1CCNB1CCNB2CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| WO-2007107221-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | CDK1 6/4885CCNB1 13/4885CCNB2 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.