Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 11/20 | 0.64 |
| ▸ | CDK1 | P06493 | 11/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.64 |
| ▸ | CCNB3 | Q8WWL7 | 11/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | CDK9 | P50750 | 2/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 9/20 | 0.61 |
| ▸ | CDC7 | O00311 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239582 | 0.83 | CCNB2 (0.71) | CCNB2CDK1CCNB1CCNB3CCNT1 | |
| SCHEMBL15721579 | 0.82 | DYRK1A (0.62) | CCNB2CDK1CCNB1CCNB3CCNT1 | |
| SCHEMBL13239588 | 0.80 | CDK1 (0.64) | CCNB2CDK1CCNB1CCNB3CYP3A4 | |
| SCHEMBL8939628 | 0.80 | CDK2 (0.69) | CCNB2CDK1CCNB1CCNB3CCNT1 | |
| SCHEMBL8939656 | 0.79 | CYP3A4 (1.00) | CCNB2CDK1CCNB1CCNB3CYP3A4 | |
| SCHEMBL2544992 | 0.78 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3CCNT1 | |
| SCHEMBL13007924 | 0.78 | CDK1 (1.00) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| Meriolin 1 SCHEMBL2241315 | 0.77 | CDK9 (1.00) | CCNB2CDK1CCNB1CCNB3ROCK1 | |
| SCHEMBL15721580 | 0.77 | DYRK1A (0.70) | CCNB2CDK1CCNB1CCNB3CCNT1 | |
| SCHEMBL3767765 | 0.77 | RET (0.77) | CCNB2CDK1CCNB1CCNB3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| WO-2007107221-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | CCNB2 24/4885CDK1 6/4885CCNB1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.