Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13964619 | 0.92 | HTR6 (0.62) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13743515 | 0.91 | HTR6 (0.60) | HTR6ALDH1A1LMNATP53MEN1 | |
| SCHEMBL14262595 | 0.89 | HTR6 (0.58) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13368569 | 0.88 | HTR6 (0.71) | HTR6ALDH1A1LMNATP53MEN1 | |
| SCHEMBL13947708 | 0.87 | HTR6 (0.54) | HTR6ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13947543 | 0.86 | HTR6 (0.55) | HTR6ALDH1A1POLBSMN1; SMN2NPSR1 | |
| SCHEMBL13947147 | 0.86 | HTR6 (0.55) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13240022 | 0.86 | HTR6 (0.55) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13947148 | 0.85 | HTR6 (0.62) | HTR6ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13946951 | 0.85 | HTR6 (0.58) | HTR6ALDH1A1LMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367828-B2 | PPAR active compounds | PLEXXIKON INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2010-08-19 | — | — | US | disclosed |
| US-7572806-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7476746-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080096913-A1 | PPAR active compounds | PLEXXIKON, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7348338-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096913-A1 | PPAR active compounds | PPARG, PPARD, PPARA | HTR6 1004/4885ALDH1A1 1171/4885LMNA 2137/4885 |
| US-20070149603-A1 | PPAR ACTIVE COMPOUNDS | PPARG, PPARD, PPARA | HTR6 1004/4885ALDH1A1 1171/4885LMNA 2137/4885 |
| US-20100210036-A1 | PPAR ACTIVE COMPOUNDS | PPARG, PPARD, PPARA | HTR6 1004/4885ALDH1A1 1171/4885LMNA 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.