Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324842 | 0.82 | IKBKB (0.56) | HIF1AMAPTRXFP1IKBKB | |
| SCHEMBL9056546 | 0.81 | MAOB (0.60) | MAPTMAOB | |
| SCHEMBL1325397 | 0.80 | HIF1A (0.49) | HIF1AMAPTIKBKB | |
| SCHEMBL8148879 | 0.79 | NR1H4 (0.71) | LRRK2MAPTRXFP1MAOB | |
| SCHEMBL6840816 | 0.79 | NR1H4 (0.61) | PPIALRRK2MAPTRXFP1RAF1 | |
| SCHEMBL1324071 | 0.79 | KDR (0.57) | HIF1AIKBKBBRAF | |
| SCHEMBL1324898 | 0.78 | KDR (0.70) | MAPTIKBKBBRAF | |
| SCHEMBL4306909 | 0.77 | MAOB (0.52) | MAOB | |
| SCHEMBL1324145 | 0.77 | KDR (0.66) | HIF1ABRAF | |
| SCHEMBL1324036 | 0.77 | KDR (0.57) | MAPTIKBKBBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |