Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324842 | 0.81 | IKBKB (0.56) | HIF1AIKBKBMAPTMEN1KMT2A | |
| SCHEMBL1324006 | 0.80 | PPIA (0.50) | HIF1AIKBKBMAPT | |
| SCHEMBL1324071 | 0.78 | KDR (0.57) | HIF1AIKBKB | |
| SCHEMBL1324145 | 0.77 | KDR (0.66) | HIF1A | |
| SCHEMBL1324898 | 0.77 | KDR (0.70) | IKBKBMAPTKDM4E | |
| SCHEMBL1324036 | 0.76 | KDR (0.57) | IKBKBMAPTKDM4E | |
| SCHEMBL4304519 | 0.74 | LMNA (0.43) | HIF1AMAPTKDM4ENPC1MEN1 | |
| SCHEMBL1324200 | 0.74 | KDR (0.53) | HIF1AMAPTKDM4E | |
| SCHEMBL1324059 | 0.70 | LMNA (0.39) | MAPTKDM4EGAAALDH1A1MAPK1 | |
| SCHEMBL10235498 | 0.69 | MAPT (0.60) | MAPTKDM4ENPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |