Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13265835 | 0.88 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265774 | 0.86 | KMT2A (0.63) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265771 | 0.85 | MAPT (0.57) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265684 | 0.85 | ALDH1A1 (0.61) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265855 | 0.84 | MAPT (0.54) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265683 | 0.83 | MAPT (0.81) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6943799 | 0.82 | MEN1 (0.54) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265766 | 0.82 | ALDH1A1 (0.56) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8855672 | 0.82 | MAPT (0.68) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13265777 | 0.81 | MAPT (0.54) | MAPTSMN1; SMN2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754773-B2 | Composition and synthesis of new reagents for inhibition of HIV replication | UNIVERSITY OF MASSACHUSETTS (US) | 2010-07-13 | — | — | US | disclosed |