Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324471 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL2208916 | 0.89 | MAP4K1 (0.38) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL2212460 | 0.89 | MAP4K1 (0.38) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL2209975 | 0.86 | NTRK1 (0.37) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL2209965 | 0.86 | NTRK1 (0.37) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL3611030 | 0.84 | CNR2 (0.35) | SMN1; SMN2MAPTXIAPRAB9AHTT | |
| SCHEMBL1323051 | 0.84 | CNR2 (0.35) | SMN1; SMN2MAPTXIAPRAB9AHTT | |
| SCHEMBL12124006 | 0.83 | BIRC2 (0.35) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL12122067 | 0.83 | ELANE (0.35) | — | |
| SCHEMBL380277 | 0.83 | ELANE (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048571-A1 | Organic Compounds | NOVARTIS AG | 2010-02-25 | — | — | US | claimed |
| CN-101595093-A | Organic compound | NOVARTIS AG (CH) | 2009-12-02 | — | — | CN | claimed |
| US-8058272-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |
| US-20100048571-A1 | Organic Compounds | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048571-A1 | Organic Compounds | XIAP, BAX, MCL1 | ALDH1A1 2759/4885KDM4E 3048/4885MEN1 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.