Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.84 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.84 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.84 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.84 |
| ▸ | CDK2 | P24941 | 4/20 | 0.84 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.84 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.84 |
| ▸ | MELK | Q14680 | 2/20 | 0.84 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.84 |
| ▸ | CDK1 | P06493 | 1/20 | 0.84 |
| ▸ | KIT | P10721 | 1/20 | 0.84 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.84 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.84 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.84 |
| ▸ | FLT4 | P35916 | 1/20 | 0.84 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.84 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.84 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.84 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.84 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nms-1286937 SCHEMBL30495915 | 0.91 | PLK1 (1.00) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3503253 | 0.90 | PLK1 (1.00) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3503422 | 0.88 | PLK1 (0.84) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3503564 | 0.86 | PLK1 (1.00) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL15377692 | 0.86 | PLK1 (0.91) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3504073 | 0.85 | PLK1 (0.89) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3503601 | 0.85 | PLK1 (1.00) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL3503742 | 0.85 | PLK1 (1.00) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL25623965 | 0.85 | PLK1 (0.88) | PLK1PLK3PLK2CCNA2CDK2 | |
| SCHEMBL25626646 | 0.84 | PLK1 (0.86) | PLK1PLK3PLK2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216808-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216808-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | MAP3K5, MAP3K9, MAP4K2 | PLK1 91/4885PLK3 121/4885PLK2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.