Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13255450 | 0.83 | RAB9A (0.48) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL13255442 | 0.80 | MAPK14 (0.38) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL13255481 | 0.79 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL13255453 | 0.72 | HPGD (0.47) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL16925413 | 0.72 | KCNA3 (0.44) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL752080 | 0.72 | ABCG2 (0.43) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL13255591 | 0.71 | CYP1A2 (0.38) | HPGDPOLBRAB9ATP53L3MBTL1 | |
| SCHEMBL13255465 | 0.69 | HPGD (0.50) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL754600 | 0.69 | RAB9A (0.49) | HPGDSMN1; SMN2POLBRAB9ATP53 | |
| SCHEMBL13255478 | 0.68 | HPGD (0.47) | HPGDSMN1; SMN2POLBRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |