Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953790 | 0.85 | GSK3B (0.44) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL953956 | 0.85 | GSK3B (0.44) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL15744122 | 0.85 | GSK3B (0.47) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL1551828 | 0.81 | GRIA2 (0.44) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL7998235 | 0.80 | PIK3CA (0.53) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL12947578 | 0.79 | CDC7 (0.55) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL1551287 | 0.79 | PIK3CA (0.74) | PIK3CAHPGDMTORSMN1; SMN2 | |
| SCHEMBL13256892 | 0.77 | GSK3B (0.41) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL7996384 | 0.77 | PIK3CA (0.52) | GSK3BGSK3ADYRK1ACLK4PIK3CA | |
| SCHEMBL13105879 | 0.76 | GSK3B (0.42) | GSK3BGSK3ADYRK1ACLK4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |