Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953790 | 0.85 | GSK3B (0.44) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL13256754 | 0.85 | GSK3B (0.44) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL953956 | 0.85 | GSK3B (0.44) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL1551828 | 0.83 | GRIA2 (0.44) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL12947578 | 0.79 | CDC7 (0.55) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL7998235 | 0.78 | PIK3CA (0.53) | GSK3BGSK3ADYRK1ACLK4KDM4E | |
| SCHEMBL1551287 | 0.77 | PIK3CA (0.74) | PIK3CAHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12947611 | 0.76 | CDC7 (0.44) | GSK3BGSK3ADYRK1ACLK4CDC7 | |
| SCHEMBL13105879 | 0.76 | GSK3B (0.42) | GSK3BGSK3ADYRK1ACLK4CDC7 | |
| SCHEMBL951777 | 0.75 | CDC7 (0.44) | GSK3BGSK3ADYRK1ACLK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313399-B1 | THIOPHENE OR THIAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARM INC (US) | 2014-05-28 | — | — | EP | disclosed |