Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954282 | 0.84 | PIK3CA (0.40) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL13105876 | 0.84 | PIK3CA (0.41) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL955529 | 0.83 | TGFBR1 (0.40) | PIK3CAMTORGSK3BGSK3AGAA | |
| SCHEMBL955202 | 0.81 | PIK3CA (0.42) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL957625 | 0.80 | IDO1 (0.38) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL952533 | 0.80 | PIK3CA (0.39) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL13256634 | 0.80 | PIK3CA (0.39) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL12947611 | 0.77 | CDC7 (0.44) | PIK3CAMTORROCK1DYRK1AGSK3B | |
| SCHEMBL13256970 | 0.74 | PIK3C3 (0.40) | PIK3C3SCN9ACYP3A4 | |
| SCHEMBL956193 | 0.73 | PIK3CA (0.40) | PIK3CAMTORDYRK1AGSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |