Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 10/20 | 0.53 |
| ▸ | CTSS | P25774 | 5/20 | 0.42 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15888839 | 0.92 | GPR142 (0.44) | GPR142CTSSCTSKCTSBCTSL | |
| SCHEMBL13258445 | 0.92 | GPR142 (0.44) | GPR142CTSSCTSKCTSBCTSL | |
| SCHEMBL2685100 | 0.91 | GPR142 (0.57) | GPR142CTSSCTSKMAPTSCN9A | |
| SCHEMBL2685102 | 0.91 | GPR142 (0.57) | GPR142CTSSCTSKMAPTSCN9A | |
| SCHEMBL5960218 | 0.88 | GPR142 (0.69) | GPR142CTSSCTSKCTSBCTSL | |
| SCHEMBL2684599 | 0.87 | GPR142 (0.60) | GPR142MAPTRAB9A | |
| SCHEMBL10284416 | 0.82 | GPR142 (0.78) | GPR142MAPTRAB9A | |
| SCHEMBL6028333 | 0.81 | HDAC4 (0.53) | GPR142CTSSCTSKCTSBCTSL | |
| SCHEMBL13258389 | 0.81 | GPR142 (0.57) | GPR142CTSSCTSKAAK1SCN9A | |
| SCHEMBL2684337 | 0.81 | GPR142 (0.53) | GPR142MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785468-B2 | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions | AMGEN INC. (US) | 2014-07-22 | — | — | US | disclosed |
| WO-2010093849-A2 | PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2010-08-19 | — | — | WO | disclosed |