GPR142 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2393752	1.00	20/20
SCHEMBL2683161	1.00	20/20
SCHEMBL2684311	1.00	20/20
SCHEMBL2684482	1.00	20/20
SCHEMBL2684485	1.00	20/20
SCHEMBL2685091	1.00	20/20
SCHEMBL2685155	1.00	20/20
SCHEMBL2685165	1.00	20/20
SCHEMBL2685195	1.00	20/20
SCHEMBL2685198	1.00	20/20
SCHEMBL2395039	0.91	20/20
SCHEMBL2395658	0.86	20/20
SCHEMBL2395538	0.85	20/20
SCHEMBL2685124	0.85	20/20
SCHEMBL2685128	0.85	20/20
SCHEMBL2685120	0.84	20/20
SCHEMBL2685130	0.84	20/20
SCHEMBL2685348	0.83	20/20
SCHEMBL2684227	0.81	20/20
SCHEMBL2684231	0.81	20/20

Clinical trials — most relevant to GPR142 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment	PHASE1/PHASE2	RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Dose Ranging Study of Carbidopa-levodopa	PHASE2	COMPLETED
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
GPRC5D Targeted PET/CT Imaging in Plasma Cell Disorders	PHASE1	NOT_YET_RECRUITING
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
A Study of OL-101 Injection in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)	PHASE1	RECRUITING
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
Investigating Glucose Metabolism of LEAP2 With Total-body PET/CT	nan	ACTIVE_NOT_RECRUITING
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR142 binder may also engage these)

Protein	Name	Similarity
Q7TQN9	—	0.981	Q7TQN9 →
Q3UN16	—	0.961	Q3UN16 →
B4XF06	—	0.958	B4XF06 →
Q9BZJ8	—	0.958	Q9BZJ8 →
Q8K0Z9	—	0.955	Q8K0Z9 →
Q96N19	—	0.953	Q96N19 →
Q16538	—	0.953	Q16538 →
Q8C010	—	0.951	Q8C010 →
P51810	—	0.950	P51810 →
Q9BZ19	—	0.945	Q9BZ19 →
Q99678	—	0.944	Q99678 →
Q86SQ6	—	0.944	Q86SQ6 →
P49220	—	0.944	P49220 →
Q8VIH9	—	0.944	Q8VIH9 →
GPER1	G-protein coupled estrogen receptor 1	0.944	landscape →
STK35	Serine/threonine-protein kinase 35	0.943	landscape →
Q6NV75	—	0.943	Q6NV75 →
CNR2	Cannabinoid receptor 2	0.942	landscape →
Q8BMP4	—	0.941	Q8BMP4 →
P41155	—	0.941	P41155 →
F7EQ49	—	0.940	F7EQ49 →
Q9Z0L1	—	0.940	Q9Z0L1 →
O08878	—	0.940	O08878 →
Q9PUQ8	—	0.940	Q9PUQ8 →
Q71SP5	—	0.940	Q71SP5 →
P49684	—	0.940	P49684 →
P47746	—	0.939	P47746 →
P20272	—	0.939	P20272 →
O02777	—	0.939	O02777 →
GPR39	G-protein coupled receptor 39	0.939	landscape →