Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 9/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791650 | 0.89 | EPHX2 (0.54) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3791622 | 0.87 | EPHX2 (0.51) | SCN5AEPHX2ROCK2ROCK1 | |
| SCHEMBL3790192 | 0.87 | SCN5A (0.43) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3790038 | 0.86 | EPHX2 (0.52) | SCN5AEPHX2ROCK2ROCK1PPARG | |
| SCHEMBL3792943 | 0.86 | EPHX2 (0.42) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3796258 | 0.86 | SCN5A (0.43) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3785767 | 0.85 | EPHX2 (0.42) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3787244 | 0.84 | SCN5A (0.40) | SCN5AEPHX2DDR1ROCK2ROCK1 | |
| SCHEMBL3789474 | 0.83 | DDR1 (0.41) | SCN5ADDR1 | |
| SCHEMBL13257875 | 0.77 | EPHX2 (0.38) | EPHX2DDR1ROCK2ROCK1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |