Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 19/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 15/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220850 | 0.91 | S1PR5 (0.50) | S1PR5S1PR1PDGFRAHTR2AKCNH2 | |
| SCHEMBL3045265 | 0.80 | PKM (0.53) | S1PR5S1PR1S1PR3 | |
| SCHEMBL3041986 | 0.72 | PDCD1 (0.57) | S1PR5S1PR1HTR2AKCNH2SIGMAR1 | |
| SCHEMBL13258706 | 0.72 | MAPT (0.55) | — | |
| SCHEMBL3033578 | 0.71 | S1PR5 (0.71) | S1PR5S1PR1PDGFRAHTR2AKCNH2 | |
| SCHEMBL3039936 | 0.70 | S1PR5 (0.81) | S1PR5S1PR1HTR2AKCNH2SIGMAR1 | |
| SCHEMBL15532870 | 0.68 | S1PR5 (0.69) | S1PR5S1PR1HTR2AKCNH2SIGMAR1 | |
| SCHEMBL3041565 | 0.68 | S1PR5 (0.76) | S1PR5S1PR1PDGFRAHTR2AKCNH2 | |
| SCHEMBL565212 | 0.67 | S1PR5 (0.87) | S1PR5S1PR1GRK5CDK8S1PR3 | |
| SCHEMBL31395097 | 0.67 | S1PR5 (0.70) | S1PR5S1PR1PDGFRAGRK5CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093704-A1 | AGONISTS AND ANTAGONISTS OF THE S1P5 RECEPTOR, AND METHODS OF USES THEREOF | ABBOTT LABORATORIES (US) | 2010-08-19 | — | — | WO | disclosed |