Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258798 | 0.88 | CHEK1 (0.55) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13259773 | 0.83 | CHEK1 (0.69) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13259792 | 0.83 | CHEK1 (0.67) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258877 | 0.82 | CHEK1 (0.73) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258780 | 0.80 | MAPKAPK2 (0.46) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL14346829 | 0.80 | CHEK1 (0.35) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13776797 | 0.77 | CHEK1 (0.55) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13764317 | 0.75 | CHEK1 (0.47) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13259850 | 0.73 | CHEK1 (0.57) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258799 | 0.71 | CHEK1 (0.57) | CHEK1MAPKAPK2JAK2LCKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088368-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2010-08-05 | — | — | WO | disclosed |