Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 12/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258798 | 0.85 | CHEK1 (0.55) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13259773 | 0.80 | CHEK1 (0.69) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13259782 | 0.80 | CHEK1 (0.49) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13259792 | 0.80 | CHEK1 (0.67) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13764317 | 0.73 | CHEK1 (0.47) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13776797 | 0.72 | CHEK1 (0.55) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13259850 | 0.70 | CHEK1 (0.57) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13258755 | 0.69 | CHEK1 (0.80) | MAPKAPK2CHEK1JAK2LCKIGF1R | |
| SCHEMBL13258778 | 0.69 | CHEK1 (0.56) | MAPKAPK2CHEK1LCKIRAK4CYP1A2 | |
| SCHEMBL13258799 | 0.68 | CHEK1 (0.57) | MAPKAPK2CHEK1JAK2LCKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088368-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2010-08-05 | — | — | WO | disclosed |