Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13261797 | 1.00 | MAPT (0.56) | MAPTGAATSHRGRM1RECQL | |
| SCHEMBL27904221 | 0.84 | GAA (0.40) | MAPTGAATSHRALDH1A1MEN1 | |
| SCHEMBL14865208 | 0.83 | GAA (0.39) | MAPTGAATSHRALDH1A1MEN1 | |
| SCHEMBL13261798 | 0.83 | GAA (0.39) | MAPTGAATSHRALDH1A1MEN1 | |
| SCHEMBL14865202 | 0.83 | GAA (0.39) | MAPTGAATSHRALDH1A1MEN1 | |
| SCHEMBL3862839 | 0.82 | HPGD (0.55) | MAPTGAATSHRRECQLALDH1A1 | |
| SCHEMBL3862845 | 0.82 | HPGD (0.55) | MAPTGAATSHRRECQLALDH1A1 | |
| SCHEMBL27768247 | 0.79 | GAA (0.43) | MAPTGAATSHRALDH1A1CHRNA7 | |
| SCHEMBL27544634 | 0.78 | TSHR (0.44) | GAATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2850253 | 0.78 | HRH3 (0.69) | MAPTGAATSHRCNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096011-A1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | WO | disclosed |