Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13261798 | 1.00 | GAA (0.39) | GAATSHRCHRNA7MAPTSIGMAR1 | |
| SCHEMBL14865208 | 1.00 | GAA (0.39) | GAATSHRCHRNA7MAPTSIGMAR1 | |
| SCHEMBL27904221 | 0.87 | GAA (0.40) | GAATSHRCHRNA7MAPTSIGMAR1 | |
| SCHEMBL13261797 | 0.83 | MAPT (0.56) | GAATSHRCHRNA7MAPTALDH1A1 | |
| SCHEMBL13261925 | 0.83 | MAPT (0.56) | GAATSHRCHRNA7MAPTALDH1A1 | |
| SCHEMBL27768247 | 0.82 | GAA (0.43) | GAATSHRCHRNA7MAPTSIGMAR1 | |
| SCHEMBL13993977 | 0.82 | CHRNA7 (0.46) | GAATSHRCHRNA7MAPTALDH1A1 | |
| SCHEMBL27544634 | 0.81 | TSHR (0.44) | GAATSHRCHRNA7SIGMAR1ALDH1A1 | |
| SCHEMBL25338167 | 0.78 | KDM4E (0.40) | GAATSHRCHRNA7MAPTALDH1A1 | |
| SCHEMBL25338170 | 0.78 | KDM4E (0.40) | GAATSHRCHRNA7MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398780-B1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2013-04-17 | — | — | EP | disclosed |