Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 4/20 | 0.52 |
| ▸ | PREP | P48147 | 4/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1326699 | 0.82 | EPHX1 (0.55) | EPHX1MAPTALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL1326848 | 0.80 | KMT2A (0.53) | MAPTGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1327327 | 0.79 | EPHX1 (0.58) | EPHX1GAAALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL1326683 | 0.78 | NPC1 (0.57) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1328072 | 0.78 | EPHX1 (0.54) | EPHX1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1327839 | 0.77 | EPHX1 (0.59) | EPHX1MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28810401 | 0.77 | TSHR (0.48) | EPHX1KMT2ARAB9AHPGD | |
| SCHEMBL8295882 | 0.77 | DPP4 (0.59) | EPHX1KDM4ESIGMAR1DPP4PREP | |
| SCHEMBL2751717 | 0.77 | EPHX1 (0.97) | EPHX1KDM4ESIGMAR1GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL1328262 | 0.77 | RAB9A (0.44) | EPHX1MAPTGAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384544-B | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH | 2014-01-22 | — | — | CN | claimed |
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | claimed |
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | GRUENENTHAL GMBH (DE) | 2009-11-19 | — | — | US | claimed |
| CN-101384544-A | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | claimed |
| CN-101384544-B | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH | 2014-01-22 | — | — | CN | disclosed |
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | GRUENENTHAL GMBH (DE) | 2009-11-19 | — | — | US | disclosed |
| CN-101384544-A | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | CNR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R | EPHX1 1526/4885KDM4E 940/4885SIGMAR1 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.