Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 13/20 | 0.76 |
| ▸ | DUSP22 | Q9NRW4 | 3/20 | 0.66 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.57 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.55 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.53 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885637 | 0.86 | CFTR (1.00) | CFTRDUSP22DUSP3DUSP26HSPD1 | |
| SCHEMBL1885634 | 0.86 | CFTR (1.00) | CFTRDUSP22DUSP3DUSP26HSPD1 | |
| SCHEMBL1888931 | 0.86 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1327129 | 0.86 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1885636 | 0.86 | CFTR (1.00) | CFTRDUSP22DUSP3DUSP26HSPD1 | |
| SCHEMBL1886439 | 0.84 | CFTR (1.00) | CFTRDUSP22DUSP26MEN1KMT2A | |
| SCHEMBL1886437 | 0.84 | CFTR (1.00) | CFTRDUSP22DUSP26MEN1KMT2A | |
| SCHEMBL8003652 | 0.84 | CFTR (1.00) | CFTRDUSP22DUSP26MEN1KMT2A | |
| SCHEMBL1326808 | 0.84 | CFTR (1.00) | CFTRDUSP22DUSP26MEN1KMT2A | |
| SCHEMBL1885081 | 0.83 | CFTR (1.00) | CFTRDUSP22DUSP3DUSP26MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058295-B2 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-11-15 | — | — | US | disclosed |
| US-20100130571-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-27 | — | — | US | disclosed |
| US-7638543-B2 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-12-29 | — | — | US | disclosed |
| US-20080064666-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-03-13 | — | — | US | disclosed |
| US-7235573-B2 | Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1549321-A4 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | UNIV CALIFORNIA (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1549321-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20040235800-A1 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-11-25 | — | — | US | disclosed |
| WO-2004028480-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130571-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | CFTR, TMEM205, TMEM33 | CFTR 1/4885DUSP22 2501/4885DUSP3 2096/4885 |
| US-20080064666-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF | CFTR, TMEM205, TMEM33 | CFTR 1/4885DUSP22 2501/4885DUSP3 2096/4885 |
| US-20040235800-A1 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof | CFTR, TMEM205, TMEM33 | CFTR 1/4885DUSP22 2501/4885DUSP3 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.