Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328216 | 0.90 | KCNA3 (0.48) | ALDH1A1HPGDTP53MEN1KMT2A | |
| SCHEMBL1326618 | 0.85 | MEN1 (0.56) | ALDH1A1TP53GAAMEN1KMT2A | |
| SCHEMBL1327346 | 0.85 | TSHR (0.55) | LMNAALDH1A1HPGDTP53GAA | |
| SCHEMBL1328446 | 0.84 | P2RX7 (0.47) | ALDH1A1HPGDTP53GAAMEN1 | |
| SCHEMBL2306307 | 0.83 | NPC1 (0.44) | LMNAPKMKMT2ANPC1RAB9A | |
| SCHEMBL1327800 | 0.81 | HPGD (0.44) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL1327650 | 0.80 | NPC1 (0.45) | ALDH1A1NAMPTMEN1KMT2ANPC1 | |
| SCHEMBL1327283 | 0.80 | KCNA3 (0.50) | LMNAALDH1A1HPGDTP53MEN1 | |
| SCHEMBL1329024 | 0.80 | NPC1 (0.48) | HPGDNPC1RAB9A | |
| SCHEMBL493116 | 0.79 | KLK7 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384544-B | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH | 2014-01-22 | — | — | CN | claimed |
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | claimed |
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | GRUENENTHAL GMBH (DE) | 2009-11-19 | — | — | US | claimed |
| CN-101384544-A | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | claimed |
| CN-101384544-B | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH | 2014-01-22 | — | — | CN | disclosed |
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | GRUENENTHAL GMBH (DE) | 2009-11-19 | — | — | US | disclosed |
| CN-101384544-A | Substituted cyclohexylmethyl derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286833-A1 | Substituted Cyclohexylmethyl Compounds | CNR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R | LMNA 1432/4885ALDH1A1 1333/4885HPGD 718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.