Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.60 |
| ▸ | WEE1 | P30291 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 14/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268185 | 0.92 | PDGFRA (0.60) | PDGFRAWEE1ALKPDGFRBBRD4 | |
| SCHEMBL13268184 | 0.92 | ALK (0.60) | PDGFRAWEE1ALKPDGFRBBRD4 | |
| SCHEMBL13268247 | 0.88 | BRD4 (0.55) | WEE1ALKBRD4JAK2RET | |
| SCHEMBL13268232 | 0.87 | BRD4 (0.62) | WEE1ALKBRD4JAK2RET | |
| SCHEMBL13268241 | 0.86 | WEE1 (0.53) | PDGFRAWEE1ALKPDGFRBBRD4 | |
| SCHEMBL3118352 | 0.86 | PDGFRA (0.63) | PDGFRAWEE1ALKPDGFRBBRD4 | |
| SCHEMBL13268015 | 0.85 | BRD4 (0.60) | ALKBRD4EGFR | |
| SCHEMBL13268023 | 0.85 | BRD4 (0.61) | WEE1ALKBRD4JAK2RET | |
| SCHEMBL3122506 | 0.85 | PDGFRA (0.59) | PDGFRAWEE1ALKPDGFRBBRD4 | |
| SCHEMBL13268040 | 0.84 | ALK (0.60) | PDGFRAWEE1ALKPDGFRBBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179134-A1 | PYRIMIDINEDIAMINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179134-A1 | PYRIMIDINEDIAMINE KINASE INHIBITORS | PLK1, TK1, DTYMK | PDGFRA 1259/4885WEE1 236/4885ALK 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.