Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | NEK2 | P51955 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268247 | 0.92 | BRD4 (0.55) | BRD4ALKJAK2RETWEE1 | |
| SCHEMBL13268038 | 0.91 | BRD4 (0.66) | BRD4ALKNEK2CHEK1AURKA | |
| SCHEMBL13268184 | 0.88 | ALK (0.60) | BRD4ALKNEK2CHEK1AURKA | |
| SCHEMBL12854635 | 0.86 | BRD4 (0.58) | BRD4ALKNEK2AXLCHEK1 | |
| SCHEMBL3114703 | 0.85 | BRD4 (0.54) | BRD4ALKNEK2AXLCHEK1 | |
| SCHEMBL13268024 | 0.82 | CTSC (0.59) | BRD4ALKNEK2CHEK1AURKA | |
| SCHEMBL13268042 | 0.82 | TNK2 (0.56) | BRD4ALKFLT3MAPK9CDK9 | |
| SCHEMBL13268233 | 0.82 | BRD4 (0.51) | BRD4ALKJAK2RETPDGFRB | |
| SCHEMBL13268245 | 0.82 | BRD4 (0.62) | BRD4ALKNEK2CHEK1AURKA | |
| SCHEMBL13268015 | 0.81 | BRD4 (0.60) | BRD4ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179134-A1 | PYRIMIDINEDIAMINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179134-A1 | PYRIMIDINEDIAMINE KINASE INHIBITORS | PLK1, TK1, DTYMK | BRD4 789/4885ALK 3686/4885NEK2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.