Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 18/20 | 0.70 |
| ▸ | ICOSLG | O75144 | 8/20 | 0.63 |
| ▸ | ICOS | Q9Y6W8 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10087550 | 0.82 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13452572 | 0.80 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253035 | 0.80 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL10087510 | 0.79 | CHUK (0.74) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13847805 | 0.79 | CHUK (0.70) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL14253042 | 0.78 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13377038 | 0.78 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL5264210 | 0.77 | CHUK (1.00) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13270196 | 0.77 | CHUK (0.41) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13270049 | 0.77 | CHUK (0.44) | CHUKICOSLGICOSMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| EP-1735311-B1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARM INC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009067233-A1 | BETA CARBOLINES AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | WO | disclosed |