Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.41 |
| ▸ | ICOSLG | O75144 | 8/20 | 0.39 |
| ▸ | ICOS | Q9Y6W8 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13270049 | 0.85 | CHUK (0.44) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL1803429 | 0.77 | CHUK (0.56) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL13268756 | 0.77 | CHUK (0.70) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL1798677 | 0.68 | CHUK (0.55) | CHUKMEN1KMT2AROCK2 | |
| SCHEMBL1798318 | 0.62 | CHUK (0.44) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL10144169 | 0.61 | CCR2 (0.33) | MEN1KMT2A | |
| SCHEMBL1798096 | 0.61 | CHUK (0.56) | CHUKICOSLGICOSROCK2 | |
| SCHEMBL29623551 | 0.60 | PIK3CA (0.33) | MEN1KMT2A | |
| SCHEMBL2768231 | 0.60 | CHUK (0.78) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL28166035 | 0.60 | CDK4 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |