Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | FLT1 | P17948 | 6/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | FLT4 | P35916 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | FRK | P42685 | 3/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.44 |
| ▸ | BLK | P51451 | 3/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.44 |
| ▸ | NEK2 | P51955 | 3/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | STK3 | Q13188 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787724 | 0.80 | SRC (0.47) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL2976034 | 0.80 | KDR (0.67) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL22096095 | 0.80 | KDR (0.45) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL14013994 | 0.78 | KDR (0.68) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL4862834 | 0.76 | CHEK1 (0.43) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL2966704 | 0.76 | AURKA (0.50) | KDRFLT1AURKAPLK4ROCK2 | |
| Ammonia Solution, Strong SCHEMBL1907515 | 0.75 | L3MBTL1 (0.39) | KDRAKT2ENPP3ENPP1MEN1 | |
| SCHEMBL14013991 | 0.73 | KDR (0.61) | KDRFLT1AURKAPLK4ROCK2 | |
| SCHEMBL13271835 | 0.72 | TNK2 (0.68) | AURKATNK2EGFRMEN1KMT2A | |
| SCHEMBL13983963 | 0.71 | KDR (0.53) | KDRFLT1AURKAPLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-B1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2010-07-14 | — | — | EP | disclosed |