Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787327 | 0.84 | TNK2 (0.48) | GSK3BKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL12607061 | 0.81 | TNK2 (0.47) | GSK3BKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4698145 | 0.75 | TNK2 (0.49) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL4753075 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL4750471 | 0.73 | TNK2 (0.47) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL1785467 | 0.72 | TNK2 (0.48) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL1786593 | 0.72 | TNK2 (0.48) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL12607170 | 0.72 | TNK2 (0.48) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL1787960 | 0.71 | TNK2 (0.48) | KDM4EALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL12607137 | 0.71 | TNK2 (0.49) | KDM4EALDH1A1HPGDNPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-B1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2010-07-14 | — | — | EP | disclosed |