Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 14/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.33 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329322 | 0.92 | C5AR1 (0.42) | C5AR1S1PR5CYP2A13 | |
| SCHEMBL1329326 | 0.92 | C5AR1 (0.42) | C5AR1S1PR5CYP2A13 | |
| SCHEMBL1329017 | 0.89 | S1PR5 (0.33) | C5AR1S1PR5KLKB1 | |
| SCHEMBL12126035 | 0.89 | S1PR5 (0.33) | C5AR1S1PR5KLKB1 | |
| SCHEMBL1327809 | 0.84 | C5AR1 (0.39) | C5AR1CYP2A13 | |
| SCHEMBL1327231 | 0.84 | CYP2A13 (0.43) | C5AR1CYP2A13SLC8A1 | |
| SCHEMBL1327923 | 0.83 | CYP2A13 (0.35) | C5AR1CYP2A13SLC8A1 | |
| SCHEMBL1329614 | 0.83 | CYP2A13 (0.35) | C5AR1CYP2A13SLC8A1 | |
| SCHEMBL1328538 | 0.83 | DRD2 (0.43) | C5AR1S1PR5 | |
| SCHEMBL1327693 | 0.83 | DRD2 (0.43) | C5AR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | HUTCHINSON ALAN J (US) | 2011-11-17 | — | — | US | disclosed |
| US-7863454-B2 | 3-substituted-6-aryl pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-01-04 | — | — | US | disclosed |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2009-07-09 | — | — | US | disclosed |
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885S1PR5 224/4885KLKB1 1738/4885 |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885S1PR5 224/4885KLKB1 1738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.