Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099750 | 0.92 | P2RX7 (1.00) | P2RX7HTR7 | |
| SCHEMBL1099251 | 0.91 | P2RX7 (0.86) | P2RX7KDM4EHTR7 | |
| SCHEMBL1099254 | 0.91 | P2RX7 (0.86) | P2RX7KDM4EHTR7 | |
| SCHEMBL1100095 | 0.87 | P2RX7 (0.84) | P2RX7HTR7 | |
| SCHEMBL1098654 | 0.87 | P2RX7 (0.84) | P2RX7HTR7 | |
| SCHEMBL1099960 | 0.86 | P2RX7 (0.88) | P2RX7HTR7 | |
| SCHEMBL1099236 | 0.85 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL1098877 | 0.85 | P2RX7 (0.84) | P2RX7KDM4E | |
| SCHEMBL1098874 | 0.85 | P2RX7 (0.84) | P2RX7KDM4E | |
| SCHEMBL1099968 | 0.84 | P2RX7 (0.79) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072599-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |