Dyrene

Dyrene

SCHEMBL13280

Clc1nc(Cl)nc(Nc2ccccc2Cl)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 1.00
NFKB1 P19838 2/20 0.59
MAPT P10636 5/20 0.56
KMT2A Q03164 5/20 0.56
KDM4E B2RXH2 2/20 0.56
ALDH1A1 P00352 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
MEN1 O00255 1/20 0.53
MAPK1 P28482 1/20 0.53
IGF1R P08069 1/20 0.51
NPSR1 Q6W5P4 2/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
RAD52 P43351 1/20 0.47
HDAC3 O15379 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
LMNA P02545 1/20 0.46
ADRA2A P08913 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dyrene SCHEMBL133054 1.00 TSHR (1.00) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL6750152 1.00 TSHR (1.00) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL1903290 1.00 TSHR (1.00) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL29364667 1.00 TSHR (1.00) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL8166670 1.00 TSHR (1.00) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL2501660 0.98 TSHR (0.96) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL6281234 0.98 TSHR (0.96) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL827164 0.98 TSHR (0.96) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL21061705 0.98 TSHR (0.96) TSHRNFKB1MAPTKMT2AKDM4E
Dyrene SCHEMBL1763275 0.98 TSHR (0.96) TSHRNFKB1MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 364723 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119264764-A Zinc-containing coating film 东丽先端材料研究开发(中国)有限公司 2025-01-07 CN claimed
CN-116355206-B Halogen-free flame-retardant transparent nylon and preparation method thereof 万华化学集团股份有限公司 2025-01-07 CN claimed
US-12187964-B2 Amelioration of solids formation in spent hydrogen sulfide scavengers CANADIAN ENERGY SERVICES L.P. (CA) 2025-01-07 US claimed
CN-119220356-A Preparation method of cleaning liquid 上海新阳半导体材料股份有限公司 2024-12-31 CN claimed
CN-119219707-A Organic electroluminescent material and device thereof 北京夏禾科技有限公司 2024-12-31 CN claimed
US-12178901-B2 Polymer and a topical composition comprising the polymer CONOPCO, INC. (US) 2024-12-31 US claimed
CN-119185642-A High-efficiency sterilization and stable dispersion nano silver dressing solution and preparation method thereof 南通金旭科技有限公司 2024-12-27 CN claimed
US-20240431130-A1 LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2024-12-26 US claimed
US-20240425539-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-12-26 US claimed
CN-119176841-A Organic electroluminescent material and device thereof 北京夏禾科技有限公司 2024-12-24 CN claimed
US-3940340-A Peracylated polyamines compatible with optical brighteners as activators for inorganic peroxo compounds HOECHST AKTIENGESELLSCHAFT (DT) 1976-02-24 US claimed
US-3940298-A Thermal laser pumped with high nitrogen content propellants THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1976-02-24 US claimed
US-3938574-A Vulcanizable rubber mixture for tire treads having improved skid resistance DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1976-02-17 US claimed
US-3937703-A PREPARATION OF RDX THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1976-02-10 US claimed
US-RE28682-E Decorative laminate ROHM & HAAS COMPANY (US) 1976-01-13 US claimed
US-3932366-A FROM AMINOCARBOXYLIC ACIDS AND TRIAMINES, FIBER REACTIVE DYES BAYER AKTIENGESELLSCHAFT (DT) 1976-01-13 US claimed
US-3932402-A Preparation of sym-triazines by trimerization of nitriles in trifluoromethanesulfonic acid PHILLIPS PETROLEUM COMPANY (US) 1976-01-13 US claimed
US-3932323-A STABILIZERS, PIGMENTS, POLYOLEFINS PHILLIPS PETROLEUM COMPANY (US) 1976-01-13 US claimed
US-3931165-A INSECTICIDES, HERBICIDES BARER SOL J 1976-01-06 US claimed
US-3930836-A SUBSTITUTED SULFONATE ANTIDOTE COMPOUNDS AND METHOD OF USE WITH HERBICIDES STAUFFER CHEMICAL COMPANY (US) 1976-01-06 US claimed