Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391518 | 1.00 | NR1H2 (0.46) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL762294 | 1.00 | NR1H2 (0.46) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL3567347 | 1.00 | NR1H2 (0.46) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL19881453 | 1.00 | NR1H2 (0.46) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL14303516 | 1.00 | NR1H2 (0.46) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL12458213 | 0.89 | NR1H2 (0.45) | NR1H2USP30USP2SMN1; SMN2EPHX1 | |
| SCHEMBL31084556 | 0.86 | EPHX1 (0.47) | NR1H2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL18502917 | 0.86 | EPHX1 (0.47) | NR1H2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL20121454 | 0.86 | EPHX1 (0.47) | NR1H2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL24098660 | 0.85 | NR1H2 (0.45) | NR1H2USP30USP2SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382214-B1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | SUNESIS PHARMACEUTICALS INC (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2010078294-A1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | SUNESIS PHARMACEUTICAL, INC. (US) | 2010-07-08 | — | — | WO | disclosed |