Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31084556 | 1.00 | EPHX1 (0.47) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL18502917 | 0.88 | EPHX1 (0.47) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL27914509 | 0.86 | EPHX1 (0.48) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL15765934 | 0.86 | EPHX1 (0.48) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL3567347 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL391518 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL13282934 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL19881453 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL14303516 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL762294 | 0.86 | NR1H2 (0.46) | EPHX1HPGDRECQLPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963448-B2 | Bicyclic inhibitors of PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-05-08 | — | — | US | disclosed |