SCHEMBL13283262

SCHEMBL13283262

CC(Nc1ncnc2ccc(Br)cc12)c1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GALR3 O60755 1/20 0.72
NR2F2 P24468 1/20 0.72
LMNA P02545 3/20 0.69
HTT P42858 2/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
EGFR P00533 11/20 0.64
KRAS P01116 1/20 0.64
SOS1 Q07889 1/20 0.64
DYRK1A Q13627 2/20 0.57
PIK3CA P42336 2/20 0.57
HDAC3 O15379 1/20 0.56
HDAC4 P56524 1/20 0.56
HDAC1 Q13547 1/20 0.56
HDAC7 Q8WUI4 1/20 0.56
HDAC2 Q92769 1/20 0.56
HDAC10 Q969S8 1/20 0.56
HDAC11 Q96DB2 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
HDAC9 Q9UKV0 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31505701 1.00 GALR3 (0.72) GALR3NR2F2LMNAHTTSMN1; SMN2
SCHEMBL31505705 1.00 GALR3 (0.72) GALR3NR2F2LMNAHTTSMN1; SMN2
SCHEMBL644489 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL9921344 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL31505709 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL24577013 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL13170943 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL24576524 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL6992336 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS
SCHEMBL29775126 0.85 GALR3 (0.70) GALR3NR2F2LMNAEGFRKRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025101914-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS HAVING IMPROVED THERAPEUTIC INDEX AGAINST SOLID TUMORS MEKANISTIC THERAPEUTICS LLC (US) 2025-05-15 WO disclosed
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-07-18 US disclosed
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-07-18 US disclosed
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-07-18 US disclosed
US-20240083868-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS MEKANISTIC THERAPEUTICS, LLC 2024-03-14 US disclosed
EP-4267554-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS Mekanistic Therapeutics LLC (US) 2023-11-01 EP disclosed
US-11673876-B2 Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors MEKANISTIC THERAPEUTICS LLC (US) 2023-06-13 US disclosed
US-11673876-B2 Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors MEKANISTIC THERAPEUTICS LLC (US) 2023-06-13 US disclosed
US-11673876-B2 Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors MEKANISTIC THERAPEUTICS LLC (US) 2023-06-13 US disclosed
US-20220213054-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS MEKANISTIC THERAPEUTICS LLC (US) 2022-07-07 US disclosed
WO-2022140456-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS MEKANISTIC THERAPEUTICS LLC (US) 2022-06-30 WO disclosed
WO-2022140456-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS MEKANISTIC THERAPEUTICS LLC (US) 2022-06-30 WO disclosed
US-20100190807-A1 CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein SENEX BIOTECHNOLOGY, INC. 2010-07-29 US disclosed
US-20090281129-A1 CDKI PATHWAY INHIBITORS AND USES THEREOF SENEX BIOTECHNOLOGY, INC. 2009-11-12 US disclosed
US-20080033000-A1 Identification of CDKI pathway inhibitors SENEX BIOTECHNOLOGY, INC. 2008-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS EGFR, ERBB2, ERBB3 GALR3 2838/4885NR2F2 1965/4885LMNA 3609/4885
US-11673876-B2 Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors EGFR, ERBB2, ERBB3 GALR3 2838/4885NR2F2 1965/4885LMNA 3609/4885
US-20220213054-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS EGFR, ERBB2, ERBB3 GALR3 2838/4885NR2F2 1965/4885LMNA 3609/4885
US-20100190807-A1 CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein MAPT, CDK5, CDKN1A GALR3 3687/4885NR2F2 1129/4885LMNA 2105/4885
US-20090281129-A1 CDKI PATHWAY INHIBITORS AND USES THEREOF CDKN1A, CDK6, CCNI GALR3 3753/4885NR2F2 1164/4885LMNA 1622/4885
US-20240083868-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS EGFR, ERBB2, ERBB3 GALR3 2838/4885NR2F2 1965/4885LMNA 3609/4885
US-20080033000-A1 Identification of CDKI pathway inhibitors CDKN1A, CDK6, CDK2 GALR3 3564/4885NR2F2 850/4885LMNA 1521/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.